王天仁;张巧霞;石瑶;汤雯珺;马捷;

• 1:西安交通大学环境与疾病相关基因教育部重点实验室
• 2:西安市第三医院医学研究中心

摘要(Abstract)：

精神分裂症作为一种慢性、致残率高的精神疾病,存在多巴胺假说、失连接假说、神经发育障碍假说、氧化应激假说等多种假说解释其发病机制。神经干细胞具有分裂分化的潜能和修复中枢损伤的作用,在中枢神经系统多个脑区广泛分布。相关研究表明,精神分裂症与胚胎神经干细胞异常和神经发生有关。目前药物治理是精神疾病的主要临床治疗手段,但不可避免地存在多种弊端。根据多巴胺假说,腹侧海马在精神分裂症的治疗中处在关键地位,是各个假说的"共同通路"。借助诱导性多能干细胞建立精神分裂症疾病模型,对疾病发病机制的研究陆续取得进展。神经干细胞在胚胎发育和神经系统发生损伤时的修复过程中发挥着重要作用,将其用于精神分裂症的治疗具有显著优势,这为精神分裂症的治疗提供了新的思路。

关键词(KeyWords)： 精神分裂症;神经干细胞;抗精神病药物;干细胞治疗;多巴胺

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目（31371298）;; 大学生创新性实验项目（GJ201910698157）;; 中华医学会医学教育分会和中国高等教育学会医学教育专业委员会2018年医学教育研究立项课题（2018B-N02199）

作者(Author): 王天仁;张巧霞;石瑶;汤雯珺;马捷;

Email:

DOI:

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